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NLRP3 agonist 1
CAS No. 2454019-69-1
NLRP3 agonist 1( —— )
Catalog No. M37305 CAS No. 2454019-69-1
NLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNLRP3 agonist 1
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NoteResearch use only, not for human use.
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Brief DescriptionNLRP3 agonist 1 (compound 23) is a potent, orally active agent that activates Caspase-1 enzyme, resulting in the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms .
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DescriptionNLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNF-κB
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TargetNOD
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RecptorNOD-like Receptor (NLR)
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Research Area——
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Indication——
Chemical Information
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CAS Number2454019-69-1
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Formula Weight280.33
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Molecular FormulaC15H16N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (356.72 mM; Ultrasonic (<80°C)
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SMILESN=1NC=CC1C=2C=CC3=C(N=C(N=C3NC4(C)CC4)N)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.?
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